Lonafarnib

Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively.


Cat. No.: EX-A1630	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	785	In-stock
250mg	1400	In-stock
500mg	2050	In-stock
1g	2885	In-stock
5g	9750	In-stock

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Synonyms	SCH66336
CAS No.	193275-84-2
Purity	>98%
Formula	C27H31Br2ClN4O2
Mol Weight	638.822
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	1] Liu M, et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res, 1998, 58(21), 4947-4956. [2] Chun KH, et al. Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells. Cancer Res, 2003, 63(16), 4796-4800. [3] Feldkamp MM, et al. Isotype-specific Ras.GTP-levels predict the efficacy of farnesyl transferase inhibitors against human astrocytomas regardless of Ras mutational status. Cancer Res, 2001, 61(11), 4425-4431.
CoA	CoA of Lonafarnib

Smiles:	NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2C3=C(CCC4=C2C(Br)=CC(Cl)=C4)C=C(Br)C=N3)CC1


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