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Product Information:

Epothilone D

Epothilone D (KOS 862) is a potent microtubule stabilizer.

Cat. No.: EX-A495    Purity: >98%
Epothilone
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg585In-stock
100mg985In-stock
200mg1585In-stock
500mg2585In-stock


SynonymsKOS 862
CAS No.189453-10-9
Purity>98%
FormulaC27H41NO5S
Mol Weight491.683
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:   [1]. Konner J, et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. Invest New Drugs. 2012 Dec;30(6):2294-302. [2]. Brunden KR, et al. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci. 2010 Oct 13;30(41):13861-6.
CoACoA of Epothilone D
Smiles:C[C@H]1CCC\C(C)=C/C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\C1=CSC(C)=N1

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