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Product Information:

SHP099

SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM.

Cat. No.: EX-A1067    Purity: >98%
SHP099
For research only, Do not use for Human!

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1g1100In-stock
2g2000In-stock
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CAS No.1801747-42-1
Purity>98%
FormulaC16H19Cl2N5
Mol Weight352.262
AppearanceSolid powder
SolubilityDMSO >10 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82.

[2]. Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535(7610):148-52.
CoACoA of SHP099
Smiles:CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=CC=CC(Cl)=C1Cl

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