PFI-2 hydrochloride

PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0 nM and (S)-PFI-2 shows inhibiting activity with IC50 value of 1.0 μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis.


Cat. No.: EX-A1604	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	1100	In-stock
1g	1580	In-stock
2g	3000	In-stock
3g	4200	In-stock
5g	5800	In-stock
10g	9800	In-stock

Send PO to E-mail:order@excenen.com; or Fax:+86 020 81619670

Discount Request


CAS No.	1627607-87-7
Purity	>98%
Formula	C23H26ClF4N3O3S
Mol Weight	535.982
Appearance	White to off-white solid powder
Solubility	Soluble in DMSO/H2O
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yuzhen Niu, et al. Revealing inhibition difference between PFI-2 enantiomers against SETD7 by molecular dynamics simulations, binding free energy calculations and unbinding pathway analysis. Sci Rep. 2017 Apr 18;7:46547. [2]. Benquan Liu, et al. Pharmacological inhibition of SETD7 by PFI-2 attenuates renal fibrosis following folic acid and obstruction injury. Eur J Pharmacol. 2021 Jun 15;901:174097.
CoA	CoA of PFI-2 hydrochloride

Smiles:	Cl.FC1=CC(=CC2=C1CNCC2)S(=O)(=O)N[C@H](CC1=CC=CC(=C1)C(F)(F)F)C(=O)N1CCCC1


		Search