KDM5-C70

KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide elevation of H3K4me3 levels.


Cat. No.: EX-A1651	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	500	In-stock
200mg	700	In-stock
500mg	1050	In-stock
1g	1550	In-stock

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CAS No.	1596348-32-1
Purity	>98%
Formula	C17H28N4O3
Mol Weight	336.4292
Appearance	solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Johansson, Catrine et al. “Structural analysis of human KDM5B guides histone demethylase inhibitor development.” Nature chemical biology vol. 12,7 (2016): 539-45. [1]. Blair, Lauren P et al. “KDM5 lysine demethylases are involved in maintenance of 3'UTR length.” Science advances vol. 2,11 e1501662. 18 Nov. 2016 [1]. Xia, Lin et al. “Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition.” Cancer immunology research vol. 9,6 (2021): 707-722.
CoA	CoA of KDM5-C70

Smiles:	CCOC(=O)C1=CC(CNCC(=O)N(CC)CCN(C)C)=NC=C1


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