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Product Information:

Umbralisib

Umbralisib (TGR1202, RP5264) is a highly specific, orally available, PI3K delta inhibitor, targeting the delta isoform with nanomolar potency.

Cat. No.: EX-A1645    Purity: >98%
Umbralisib
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg550In-stock
200mg850In-stock
500mg1250In-stock
1g1850In-stock
5g5650In-stock


SynonymsTGR1202
CAS No.1532533-67-7
Purity>98%
FormulaC31H24F3N5O3
Mol Weight571.5492
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Deng C, Lipstein MR, Scotto L, Jirau Serrano XO, Mangone MA, Li S, Vendome J, Hao Y, Xu X, Deng SX, Realubit RB, Tatonetti NP, Karan C, Lentzsch S, Fruman DA, Honig B, Landry DW, O'Connor OA. Silencing c-Myc translation as a therapeutic strategy through targeting PI3K delta and CK1 epsilon in hematological malignancies. Blood. 2016 Oct 26. pii: blood-2016-08-731240. [Epub ahead of print] PubMed PMID: 27784673.

[2]. Locatelli SL, Careddu G, Inghirami G, Castagna L, Sportelli P, Santoro A, Carlo-Stella C. The novel PI3K-δ inhibitor TGR-1202 enhances Brentuximab Vedotin-induced Hodgkin lymphoma cell death via mitotic arrest. Leukemia. 2016 Sep 2. doi: 10.1038/leu.2016.224. [Epub ahead of print] PubMed PMID: 27499137.

[3].Brown JR. The PI3K pathway: clinical inhibition in chronic lymphocytic leukemia. Semin Oncol. 2016 Apr;43(2):260-4. doi:10.1053/j.seminoncol.2016.02.004. Review. PubMed PMID: 27040704.

[4]. Swaroop Vakkalankaa, et al. Inhibition of PI3Kδ kinase by a selective, small molecule inhibitor suppresses B-cell proliferation and leukemic cell growth.
CoACoA of Umbralisib
Smiles:CC(C)OC1=C(F)C=C(C=C1)C1=NN([C@@H](C)C2=C(C3=CC(F)=CC=C3)C(=O)C3=CC(F)=CC=C3O2)C2=C1C(N)=NC=N2

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