GNE-3511

GNE-3511 is an orally active bioavailable and brain-penetrant dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM. GNE-3511 can cross the blood-brain-barrier and can be used for the research of neurodegenerative disease.


Cat. No.: EX-A1294	Purity: >98%

	Chemical structure of GNE-3511

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	650	In-stock
500mg	900	In-stock
1g	1600	In-stock
5g	5500	In-stock

Send PO to E-mail:order@excenen.com; or Fax:+86 020 81619670

Discount Request


CAS No.	1496581-76-0
Purity	>98%
Formula	C23H26F2N6O
Mol Weight	440.4889
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Patel S et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem. 2015 Jan 8;58(1):401-18. [2]. Chen Jiang, et al. Neuronal Dual Leucine Zipper Kinase Mediates Inflammatory and Nociceptive Responses in Cyclophosphamide-Induced Cystitis. J Innate Immun
CoA	CoA of GNE-3511

Smiles:	FC1(F)CCN(C1)C1=CC(=CC(NC2=CC(=CC=N2)C#N)=N1)C1CCN(CC1)C1COC1


		Search