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Product Information:

CCT245737

CCT245737 is an orally active and seletive Chk1 inhibitor, with an IC50 of 1.3 nM.

Cat. No.: EX-A1607    Purity: >98%
CCT245737
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg485In-stock
200mg685In-stock
500mg985In-stock
1g1485In-stock
5g5200In-stock
10g8300In-stock


SynonymsCCT-245737
CAS No.1489389-18-5
Purity>98%
FormulaC16H16F3N7O
Mol Weight379.3397
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Osborne JD, et al. Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). J Med Chem. 2016 Jun 9;59(11):5221-37.

[2]. Walton MI, et al. The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma.

CoACoA of CCT245737
Smiles:FC(F)(F)C1=CN=C(NC2=CN=C(C=N2)C#N)C=C1NC[C@H]1CNCCO1

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