background


Product Information:

PF-06463922

Lorlatinib (PF-06463922) is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.

Cat. No.: EX-A828    Purity: >99%
PF-06463922
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g495In-stock
5g1600In-stock
10g2295In-stock


SynonymsLorlatinib
CAS No.1454846-35-5
Purity>99%
FormulaC21H19FN6O2
Mol Weight406.413
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Johnson TW, et al. Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. J Med Chem. 2014, 57(11), 4720-4744.
CoACoA of PF-06463922
Smiles:C[C@H]1OC2=C(N)N=CC(=C2)C2=C(C#N)N(C)N=C2CN(C)C(=O)C2=C1C=C(F)C=C2

KEYWORDS: buy PF-06463922 | PF-06463922 supplier | purchase | cost | manufacturer | order | distributor | buy 1454846-35-5 | 1454846-35-5 supplier