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Product Information:

Siremadlin

Siremadlin (NVP-HDM201) is a potent and highly specific MDM-2/p53 inhibitor.

Cat. No.: EX-A1631    Purity: >98%
Siremadlin
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg785In-stock
250mg1385In-stock
500mg2085In-stock
1g3285In-stock
5g9650In-stock


SynonymsNVP-HDM201
Synonyms 2HDM201
CAS No.1448867-41-1
Purity>98%
FormulaC26H24Cl2N6O4
Mol Weight555.413
AppearanceSolid powder
SolubilityDMSO > 50mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Chapeau EA, et al. Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3151-3156.

[2]. Furet P, et al. Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4837-41.

[3]. Holzer, Philipp. “Discovery of Potent and Selective p53-MDM2 Protein-Protein Interaction Inhibitors as Anticancer Drugs.” Chimia vol. 71,10 (2017): 716-721.

CoACoA of Siremadlin
Smiles:COC1=NC(OC)=C(C=N1)C1=NC2=C([C@@H](N(C2=O)C2=CC(Cl)=CN(C)C2=O)C2=CC=C(Cl)C=C2)N1C(C)C

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