EPZ6438

Tazemetostat is an orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyltransferase EZH2, with potential antineoplastic activity. Upon oral administration, Tazemetostat selectively inhibits the activity of both wild-type and mutated forms of EZH2. Inhibition of EZH2 specifically prevents the methylation of histone H3 lysine 27 (H3K27).


Cat. No.: EX-A509	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	285	In-stock
500mg	400	In-stock
1g	600	In-stock
5g	1650	In-stock
10g	2450	In-stock

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Synonyms	Tazemetostat
CAS No.	1403254-99-8
Purity	>98%
Formula	C34H44N4O4
Mol Weight	572.7376
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Knutson, Sarah K et al. “Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.” Proceedings of the National Academy of Sciences of the United States of America vol. 110,19 (2013): 7922-7.
CoA	CoA of EPZ6438

Smiles:	CCN(C1CCOCC1)C1=C(C)C(=CC(=C1)C1=CC=C(CN2CCOCC2)C=C1)C(=O)NCC1=C(C)C=C(C)NC1=O


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