KPT330

Selinexor (KPT-330) is an orally available, small molecule inhibitor of CRM1 (chromosome region maintenance 1 protein, exportin 1 or XPO1), with potential antineoplastic activity.


Cat. No.: EX-A870	Purity: >99%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	450	In-stock
500mg	650	In-stock
1g	925	In-stock
2g	1550	In-stock
5g	3200	In-stock
10g	4800	In-stock

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Synonyms	Selinexor
Synonyms 2	KPT-330
CAS No.	1393477-72-9
Purity	>99%
Formula	C17H11F6N7O
Mol Weight	443.306
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Etchin J, et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 2013 Apr;161(1):117-27. [2]. Tai YT, et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia. 2014 Jan;28(1):155-65.
CoA	CoA of KPT330

Smiles:	FC(F)(F)C1=CC(=CC(=C1)C1=NN(C=N1)\C=C/C(=O)NNC1=NC=CN=C1)C(F)(F)F


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