CPI-0610

CPI-0610 is a potent, selective, and cell-active BET inhibitor. CPI-0610 inhibits BRD4-BD1 with an IC50 of 39 nM, and with an EC50 value of 0.18 μM for MYC.


Cat. No.: EX-A1612	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	600	In-stock
250mg	900	In-stock
500mg	1300	In-stock
1g	1900	In-stock
5g	5650	In-stock
10g	7800	In-stock

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Synonyms	Pelabresib
CAS No.	1380087-89-7
Purity	>98%
Formula	C20H16ClN3O2
Mol Weight	365.813
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Albrecht BK, et al. Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials. J Med Chem. 2016 Feb 25;59(4):1330-9. [2]. Siu KT, et al. Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma. Leukemia. 2017 Aug;31(8):1760-1769.
CoA	CoA of CPI-0610

Smiles:	CC1=NOC2=C1C1=CC=CC=C1C(=N[C@H]2CC(N)=O)C1=CC=C(Cl)C=C1


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