GSK2636771

GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with a Ki of 0.89 nM and an IC50 of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms.


Cat. No.: EX-A434	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	600	In-stock
500mg	800	In-stock
1g	1250	In-stock
5g	3850	In-stock
10g	5950	In-stock

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CAS No.	1372540-25-4
Purity	>98%
Formula	C22H22F3N3O3
Mol Weight	433.4236
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Weigelt B, et al. PI3K pathway dependencies in endometrioid endometrial cancer cell lines. Clin Cancer Res. 2013, 19(13), 3533-3544. [2]. Hosford SR, et al. Combined inhibition of both p110α and p110β isoforms of phosphatidylinositol 3-kinase is required for sustained therapeutic effect in PTEN-deficient, ER+ breast cancer. Clin Cancer Res. 2016 Nov 30
CoA	CoA of GSK2636771

Smiles:	CC1=NC2=C(C=C(C=C2N1CC1=CC=CC(=C1C)C(F)(F)F)N1CCOCC1)C(O)=O


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