P505-15

PRT062607 (P505-15, BIIB057) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.


Cat. No.: EX-A1592	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	550	In-stock
250mg	885	In-stock
500mg	1285	In-stock
1g	1785	In-stock
5g	5655	inquire
10g	8485	inquire

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Synonyms	PRT062607
Synonyms 2	PRT-2607
CAS No.	1370261-96-3
Purity	>98%
Formula	C19H23N9O
Mol Weight	393.4456
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1] Coffey G, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther, 2012, 340(2), 350-359. [2] Hoellenriegel J, et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration. Leukemia, 2012, 26(7), 1576-1583.
CoA	CoA of P505-15

Smiles:	N[C@H]1CCCC[C@H]1NC1=NC(NC2=CC=CC(=C2)N2N=CC=N2)=C(C=N1)C(N)=O


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