E-7046

Palupiprant (E7046) is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM. Palupiprant exhibits anti-tumor activities.


Cat. No.: EX-A1726	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	450	In-stock
500mg	685	In-stock
1g	925	In-stock
5g	2725	In-stock
10g	3925	In-stock

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Synonyms	Palupiprant
CAS No.	1369489-71-3
Purity	>98%
Formula	C22H18F5N3O4
Mol Weight	483.388
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. X. Bao, et al. Combination of a Novel EP4 Antagonist E7046 and Radiation Therapy Promotes Anti-tumor Immune Response and Tumor Rejection in Preclinical Tumor Models. International Journal of Radiation Oncology Biology Physics [2]. Diana I. Albu, et al. EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity. OncoImmunology.
CoA	CoA of E-7046

Smiles:	C[C@H](NC(=O)C1=C(OC2=CC=CC(=C2)C(F)(F)F)N(C)N=C1C(F)F)C1=CC=C(C=C1)C(O)=O


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