EW-7197

Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect.


Cat. No.: EX-A1738	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	350	In-stock
200mg	450	In-stock
500mg	650	In-stock
1g	950	In-stock
5g	2650	In-stock
10g	3875	In-stock

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Synonyms	Vactosertib
Synonyms 2	TEW-7197
CAS No.	1352608-82-2
Purity	>98%
Formula	C22H18FN7
Mol Weight	399.4236
Appearance	Light yellow to yellow solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Son JY et al. EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis, 2014 Jul, 13(7):1704-16. [2]. Naka K, et al. Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells. Cancer Sci. 2016 Feb;107(2):140-8.
CoA	CoA of EW-7197

Smiles:	CC1=CC=CC(=N1)C1=C(N=C(CNC2=CC=CC=C2F)N1)C1=CN2N=CN=C2C=C1


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