GSK126

GSK126 (GSK2816126A, GSK2816126) is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other human methyltransferases.


Cat. No.: EX-A499	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	650	In-stock
500mg	950	In-stock
1g	1450	In-stock
2g	2600	In-stock
5g	4800	In-stock
10g	7600	In-stock

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CAS No.	1346574-57-9
Purity	>98%
Formula	C31H38N6O2
Mol Weight	526.6724
Appearance	solid powder
Solubility	Soluble in DMSO; Ethanol: Insoluble
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. McCabe, Michael T et al. “EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.” Nature vol. 492,7427 (2012): 108-12. [2]. Ott, Heidi M et al. “A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.” Molecular cancer therapeutics vol. 13,12 (2014): 3062-73 [3]. Takeshima, Hideyuki et al. “Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy.” Carcinogenesis vol. 36,2 (2015): 192-201.
CoA	CoA of GSK126

Smiles:	CC[C@H](C)N1C=C(C)C2=C1C=C(C=C2C(=O)NCC1=C(C)C=C(C)NC1=O)C1=CC=C(N=C1)N1CCNCC1


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