GSK2330672

GSK2330672 (Linerixibat) is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT; IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively).


Cat. No.: EX-A1180	Purity: >98%

	Chemical structure of GSK2330672

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	795	In-stock
100mg	1100	In-stock
250mg	1850	In-stock
500mg	2650	In-stock
1g	3900	In-stock
5g	get quote	inquire

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Synonyms	Linerixibat
CAS No.	1345982-69-5
Purity	>98%
Formula	C28H38N2O7S
Mol Weight	546.676
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wu Y, et al. Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem. 2013 Jun 27;56(12):5094-114. [2]. Wang Y, et al. HNF4α Regulates CSAD to Couple Hepatic Taurine Production to Bile Acid Synthesis in Mice. Gene Expr. 2018 Aug 22;18(3):187-196. [3]. Linerixibat (GSK2330672) granted Orphan Status. September 24, 2019./p>
CoA	CoA of GSK2330672

Smiles:	CCCC[C@]1(CC)CS(=O)(=O)C2=CC(CNC(CC(O)=O)CC(O)=O)=C(OC)C=C2[C@H](N1)C1=CC=CC=C1


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