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Product Information:

CFI-400945

CFI-400945 free base is a potent, selective and orally bioavailable PLK4 inhibitor with a Ki and an IC50 of 0.26 nM and 2.8 nM, respectively.

Cat. No.: EX-A1609    Purity: >98%
CFI-400945
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg685In-stock
250mg1185In-stock
500mg1985In-stock
1g3500In-stock
2g5800In-stock
5gGet quoteIn-stock


CAS No.1338806-73-7
Purity>98%
FormulaC33H34N4O3
Mol Weight534.6481
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Sampson PB, et al. The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent. J Med Chem. 2015 Jan 8;58(1):147-69. http://dx.doi.org/10.1021/jm5005336

[2]. Mason JM, et al. Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer Cell. 2014 Aug 11;26(2):163-76.
CoACoA of CFI-400945
Smiles:COC1=CC2=C(NC(=O)[C@@]22C[C@H]2C2=CC=C3C(NN=C3\C=C\C3=CC=C(CN4C[C@H](C)O[C@H](C)C4)C=C3)=C2)C=C1

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