OTS514

OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.


Cat. No.: EX-A1466	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	890	In-stock
500mg	1300	In-stock
1g	2100	In-stock
5g	6500	In-stock
10g	11000	In-stock

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Synonyms	9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one
CAS No.	1338540-63-8
Purity	>98%
Formula	C21H20N2O2S
Mol Weight	364.461
Appearance	A crystalline solid
Solubility	DMSO: 30 mg/ml
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145. [2]. Stefka AT, et al. Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models. Cancer Med. 2020 Jan;9(1):324-334. [3] Ikeda Y, et al. T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer. Clin Cancer Res. 2016, 22(24):6110-6117.
CoA	CoA of OTS514

Smiles:	C[C@@H](CN)C1=CC=C(C=C1)C1=C(O)C=C(C)C2=C1C1=C(SC=C1)C(=O)N2


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