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Product Information:

NG25

NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.

Cat. No.: EX-A1538    Purity: >98%
NG25
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg750In-stock
250mg1150In-stock
500mg1650In-stock
1g2450In-stock
5g6800Inquire
10g10680Inquire


SynonymsNG-25
CAS No.1315355-93-1
Purity>98%
FormulaC29H30F3N5O2
Mol Weight537.576
Appearancesolid powder
SolubilitySoluble in DMSO, not in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Tan L, et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.

[2]. Wang Z, et al. TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells. Sci Rep. 2016 Sep 7;6:32737.

CoACoA of NG25
Smiles:CCN1CCN(CC2=CC=C(NC(=O)C3=CC(OC4=C5C=CNC5=NC=C4)=C(C)C=C3)C=C2C(F)(F)F)CC1

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