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Product Information:

I-BET151

I-BET151 is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.

Cat. No.: EX-A1561    Purity: >98%
I-BET151
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg450In-stock
200mg700In-stock
500mg1050In-stock
1g1550In-stock
5g4650In-stock
10g6975In-stock


SynonymsGSK1210151A
Synonyms 2I-BET 151
CAS No.1300031-49-5
Purity>98%
FormulaC23H21N5O3
Mol Weight415.4445
Appearancewhite to off-white powder
SolubilityDMSO >100 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Seal J, et al. Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72.

[2]. Chaidos A, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123(5):697-705.

CoACoA of I-BET151
Smiles:COC1=C(C=C2N=CC3=C(N([C@H](C)C4=CC=CC=N4)C(=O)N3)C2=C1)C1=C(C)ON=C1C

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