PF-3084014

Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers.


Cat. No.: EX-A855	Purity: >99%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	750	In-stock
500mg	1050	In-stock
1g	1485	In-stock
5g	4650	In-stock
10g	7800	In-stock

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Synonyms	Nirogacestat
Synonyms 2	PF-03084014
CAS No.	1290543-63-3
Purity	>99%
Formula	C27H41F2N5O
Mol Weight	489.6441
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wei P, et al. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther. 2010 Jun;9(6):1618-28.
CoA	CoA of PF-3084014

Smiles:	CCC[C@H](N[C@H]1CCC2=C(C1)C(F)=CC(F)=C2)C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C


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