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Product Information:

NMS-P118

NMS-P118 is an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP-1).

Cat. No.: EX-A1271    Purity: >98%
NMS-P118
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg550In-stock
500mg850In-stock
1g1285In-stock
5g3855In-stock
10g5785In-stock


CAS No.1262417-51-5
Purity>98%
FormulaC20H24F3N3O2
Mol Weight395.4187
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Papeo G, et al. Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J Med Chem. 2015, 58(17):6875-98.
CoACoA of NMS-P118
Smiles:NC(=O)C1=CC(F)=CC2=C1C(=O)N(C2)C1CCN(CC1)C1CCC(F)(F)CC1

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