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Product Information:

GSK-525762A

GSK525762A (I-BET762; Molibresib) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.

Cat. No.: EX-A462    Purity: >98%
GSK-525762A
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg885In-stock
500mg1185In-stock
1g1685In-stock
5g4885In-stock


SynonymsI-BET 762
CAS No.1260907-17-2
Purity>98%
FormulaC22H22ClN5O2
Mol Weight423.895
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Nicodeme E, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23.

[2]. Asangani IA, et al. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer. Nature. 2014 Jun 12;510(7504):278-82.

[3]. Chaidos A, et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123(5):697-705.

CoACoA of GSK-525762A
Smiles:CCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(C=CC(OC)=C2)N2C(C)=NN=C12

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