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Product Information:

CDK4-IN-1

CDK4 inhibitor is a selective inhibitor of cyclin-dependent kinase 4 with IC50 value of 10 nM. Cyclin-dependent kinase 4 (CDK4) is a Ser/Thr protein kinase and is a member of the cyclin-dependent kinase family. CDK4 plays an important role in the G1-S phase.

Cat. No.: EX-A1051    Purity: >98%
CDK4-IN-1
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg1250In-stock
250mg1965In-stock
5g97506 weeks


SynonymsCDK 4/6 Inhibitor
Synonyms 2LEE011 analog
CAS No.1256963-02-6
Purity>98%
FormulaC22H29ClN8
Mol Weight440.972
AppearanceSolid powder
SolubilityDMSO > 50 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Cho YS, Borland M, Brain C, et al. 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem, 2010, 53(22): 7938-7957.
CoACoA of CDK4-IN-1
Smiles:CC(C)C1=NNC(Cl)=C1C1=NC(NC2=NC=C(C=C2)N2CCC(CC2)N(C)C)=NC=C1

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