Tubastatin A

Tubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).


Cat. No.: EX-A685	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	450	In-stock
1g	685	In-stock
2g	1065	In-stock
5g	1885	In-stock
10g	2885	In-stock

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CAS No.	1252003-15-8
Purity	>98%
Formula	C20H21N3O2
Mol Weight	335.3996
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846 [2]. Kozyreva VK, et al. NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res. 2014 May;12(5):681-93. [3]. de Zoeten EF, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78.
CoA	CoA of Tubastatin A

Smiles:	CN1CCC2=C(C1)C1=C(C=CC=C1)N2CC1=CC=C(C=C1)C(=O)NO


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