Siponimod

Siponimod (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4, with EC50s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research.


Cat. No.: EX-A873	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	400	In-stock
500mg	600	In-stock
1g	900	In-stock
5g	3250	In-stock
10g	4950	In-stock
25g	9600	In-stock

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Synonyms	BAF-312
CAS No.	1230487-00-9
Purity	>98%
Formula	C29H35F3N2O3
Mol Weight	516.595
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gergely P, et al. The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate. Br J Pharmacol. 2012 Nov;167(5):1035-47. [2]. Pan S, et al. Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. [3]. McGinley M, et al. Prospects of siponimod in secondary progressive multiple sclerosis. Ther Adv Neurol Disord. 2018 Jul 17;11:1756286418788013. [4]. Behrangi N, et al. Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action. Cells. 2019 Jan 7;8(1):24.
CoA	CoA of Siponimod

Smiles:	CCC1=CC(=CC=C1CN1CC(C1)C(O)=O)C(\C)=N/OCC1=CC=C(C2CCCCC2)C(=C1)C(F)(F)F


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