StemRegenin 1

StemRegenin 1 (SR1) is a selective reversible antagonist of the aryl hydrocarbon receptor with a value of 50% inhibition concentration IC50 of 127 nM in CD34+ cells. It is reported to promote the self-renewal of human hematopoietic stem cells in culture by sustaining the cellular expression of CD34. StemRegenin 1 also stimulates the proliferation and differentiation of CD34+ hematopoietic progenitor cells into dendritic cells.


Cat. No.: EX-A226	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	500	In-stock
500mg	700	In-stock
1g	985	In-stock
2g	1650	In-stock
5g	2850	inquire

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Synonyms	SR1
CAS No.	1227633-49-9
Purity	>98%
Formula	C24H23N5OS
Mol Weight	429.537
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Thordardottir, S., et al. The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. Stem cells and development, 2013, 23(9), 955-967. [2]. Boitano, A. E., , et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science, 2010, 329(5997), 1345-1348. [3]. Gori, J. L., et al. Efficient generation, purification, and expansion of CD34+ hematopoietic progenitor cells from nonhuman primate–induced pluripotent stem cells. Blood, 2012, 120(13), e35-e44
CoA	CoA of StemRegenin 1

Smiles:	CC(C)N1C=NC2=C(NCCC3=CC=C(O)C=C3)N=C(N=C12)C1=CSC2=CC=CC=C12


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