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Product Information:

BYL719

Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.

Cat. No.: EX-A405    Purity: >99%
BYL719
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg550In-stock
1g850In-stock
5g2550In-stock
10g3850In-stock


SynonymsAlpelisib
Synonyms 2BYL-719
CAS No.1217486-61-7
Purity>99%
FormulaC19H22F3N5O2S
Mol Weight441.47
AppearanceSolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1] Chen H, Wong CC, et al. "APLN promotes hepatocellular carcinoma through activating PI3K/Akt pathway and is a druggable target." Theranostics. 2019 Jul 9;9(18):5246-5260. PMID:31410213
CoACoA of BYL719
Smiles:CC1=C(SC(NC(=O)N2CCC[C@H]2C(N)=O)=N1)C1=CC(=NC=C1)C(C)(C)C(F)(F)F

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