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Product Information:

N6022

N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor with IC50 of 8 nM.

Cat. No.: EX-A343    Purity: >98%
N6022
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg885In-stock
500mg1385In-stock
1g2285In-stock
5g7850Inquire


CAS No.1208315-24-5
Purity>98%
FormulaC24H22N4O3
Mol Weight414.4565
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Sun X, et al. Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3671-5.

[2]. Colagiovanni DB, et al. A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma. Regul Toxicol Pharmacol. 2012 Feb;62(1):115-24.

[3]. Green LS, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51(10):2157-68.

CoACoA of N6022
Smiles:CC1=C(C=CC(=C1)C(N)=O)N1C(CCC(O)=O)=CC=C1C1=CC=C(C=C1)N1C=CN=C1

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