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Product Information:

Duvelisib

Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays.

Cat. No.: EX-A1562    Purity: >99%
Duvelisib
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
5g2000In-stock
10g3000In-stock
25g4800In-stock
50gGet quoteIn-stock
100gGet quoteIn-stock


SynonymsIPI-145
Synonyms 2INK 1197
CAS No.1201438-56-3
Purity>99%
FormulaC22H17ClN6O
Mol Weight416.863
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Pillinger G, et al. Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection. Oncotarget. 2016 Jun 28;7(26):39784-39795.

[2]. G?ckeritz E, et al. Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells. Int J Cancer. 2015 Nov 1;137(9):2234-42.
CoACoA of Duvelisib
Smiles:C[C@H](NC1=NC=NC2=C1N=CN2)C1=CC2=CC=CC(Cl)=C2C(=O)N1C1=CC=CC=C1

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