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Product Information:

PSI-7977

Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM.

Cat. No.: EX-A389    Purity: >99.9%
PSI-7977
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg285In-stock
500mg365In-stock
1g585In-stock
5g960In-stock
10g1485In-stock


SynonymsSofosbuvir
CAS No.1190307-88-0
Purity>99.9%
FormulaC22H29FN3O9P
Mol Weight529.4525
AppearanceSolid powder
Solubility

DMSO : 50 mg/mL (94.44 mM; Need ultrasonic)

H2O : 25 mg/mL (47.22 mM; ultrasonic and warming and heat to 50°C)

Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47.

[2]. Lam AM, et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68.

[3]. Sofia MJ, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18.

[4]. Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.

CoACoA of PSI-7977
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