CYT-387

Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50a of 11 nM and 18 nM,respectively. CYT387 shows much less activity against JAK3.


Cat. No.: EX-A260	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	385	In-stock
500mg	585	In-stock
1g	885	In-stock
2g	1385	In-stock
5g	2685	In-stock
10g	4028	In-stock

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Synonyms	Momelotinib free base
Synonyms 2	CYT 11387
CAS No.	1056634-68-4
Purity	>98%
Formula	C23H22N6O2
Mol Weight	414.4598
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pardanani A, et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia, 2009, 23(8), 1441-1445. [2]. Monaghan KA, et al. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia, 2011, 25(12), 1891-1899.
CoA	CoA of CYT-387

Smiles:	O=C(NCC#N)C1=CC=C(C=C1)C1=NC(NC2=CC=C(C=C2)N2CCOCC2)=NC=C1


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