R428

Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).


Cat. No.: EX-A1720	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	425	In-stock
250mg	550	In-stock
500mg	850	In-stock
1g	1350	In-stock
5g	4275	In-stock
10g	6865	In-stock

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Synonyms	Bemcentinib
Synonyms 2	BGB-324
CAS No.	1037624-75-1
Purity	>98%
Formula	C30H34N8
Mol Weight	506.6446
Appearance	Solid powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Holland SJ, Pan A, Franci C, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010;70(4):1544-1554. [2]. Sensi M, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011 Dec;131(12):2448-57. [3]. Lijnen HR, et al. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther. 2011 May;337(2):457-64.
CoA	CoA of R428

Smiles:	NC1=NC(NC2=CC3=C(CC[C@@H](CC3)N3CCCC3)C=C2)=NN1C1=NN=C2C(CCCC3=CC=CC=C23)=C1


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