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Product Information:

NMS-1286937

NMS-1286937 (NMS-P937) is a potent, selective and orally available PLK1 inhibitor, with an IC50 of 2 nM.

Cat. No.: EX-A1590    Purity: >99%
NMS-1286937
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg485In-stock
250mg685In-stock
500mg985In-stock
1g1485In-stock
5g5385In-stock
10gGet quoteIn-stock


SynonymsNMS-P937
Synonyms 2Onvansertib
CAS No.1034616-18-6
Purity>99%
FormulaC24H27F3N8O3
Mol Weight532.5182
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Beria I, et al. NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):2969-74.

[2]. Valsasina B, et al. NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies. Mol Cancer Ther. 2012 Apr;11(4):1006-16.

[3]. Casolaro A, et al. The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia. PLoS One. 2013;8(3):e58424.

CoACoA of NMS-1286937
Smiles:CN1CCN(CC1)C1=CC=C(OC(F)(F)F)C(NC2=NC=C3CCC4=C(N(CCO)N=C4C(N)=O)C3=N2)=C1

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