LCL161

LCL161 is an oral small molecule antagonist of Apoptosis Proteins (IAPs) that sensitizes a subset of tumors from diverse lineages to treatment with cytotoxic therapies.

LCL161, a SMAC mimetic, effectively binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).


Cat. No.: EX-A533	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	895	In-stock
1g	1250	In-stock
5g	5500	In-stock
10g	8800	In-stock

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CAS No.	1005342-46-0
Purity	>98%
Formula	C26H33FN4O3S
Mol Weight	500.629
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Weisberg E, et al. Leukemia, 2010, 24(12), 2100-2109. [2]. Houghton PJ, et al. Pediatr Blood Cancer, 2012, 58(4), 636-639. [3]. Knights AJ, et al. Cancer Immunol Immunother, 2013, 62(2), 321-335.
CoA	CoA of LCL161

Smiles:	CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C1=NC(=CS1)C(=O)C1=CC=C(F)C=C1


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