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Product Information:

Aprocitentan

Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist.

Cat. No.: EX-A4419    Purity: >98%
Aprocitentan
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg525In-stock
50mg685In-stock
100mg885In-stock
250mg1185In-stock
1g1685In-stock
5g4885inquire


SynonymsACT-132577
CAS No.1103522-45-7
Purity>98%
FormulaC16H14Br2N6O4S
Mol Weight546.193
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Iglarz M, et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45.

[2]. Zhang J, et al. Pharmacokinetic study of ACT-132577 in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry. Int J Clin Exp Med. 2015 Oct 15;8(10):18420-6

CoACoA of Aprocitentan
Smiles:O=S(N)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O

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