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Product Information:

Alvespimycin hydrochloride

Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.

Cat. No.: EX-A4128    Purity: >98%
Alvespimycin
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg650In-stock
1g885In-stock
5g2250In-stock


Synonyms17-DMAG hydrochloride
Synonyms 2BMS 826476
CAS No.467214-21-7
Purity>98%
FormulaC32H49ClN4O8
Mol Weight653.206
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Ge J, et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem. 2006 Jul 27;49(15):4606-15.

[2]. Hertlein E, et al. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood. 2010 Jul 8;116(1):45-53.

[3]. Henke A, et al. Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90. Cancers (Basel). 2016 Aug 24;8(9). pii: E77.

CoACoA of Alvespimycin hydrochloride
Smiles:C/C1=C\C=C/[C@@H]([C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](CC(C(C(NC1=O)=CC2=O)=O)=C2NCCN(C)C)C)OC)O[H])C)OC(N)=O)OC.Cl

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