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Product Information:

BK-1361

BK-1361(cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM.

Cat. No.: EX-A4061    Purity: >98%
BK-1361
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg785In-stock
50mg1185In-stock
100mg1785In-stock
200mg2785In-stock


SynonymsBK1361
Synonyms 2cyclo-RLsKDK
CAS No.1975145-82-4
Purity>98%
FormulaC31H57N11O9
Mol Weight727.8526
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Schlomann, Uwe et al. “ADAM8 as a drug target in pancreatic cancer. Nature communications vol. 6 6175. 28 Jan. 2015, doi:10.1038/ncomms7175

[2]. Chen, Jun et al. “A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models. Scientific reports vol. 6 30451. 26 Jul. 2016, doi:10.1038/srep30451

[3]. Yim, Victor et al. “Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis. Bioorganic & medicinal chemistry vol. 24,18 (2016): 4032-4037. doi:10.1016/j.bmc.2016.06.042

CoACoA of BK-1361
Smiles:O=C(N[C@@H](CCCCN)C(N[C@H](CC(O)=O)C(N[C@@H](C(N[C@@H](C(N[C@@H]1CC(C)C)=O)CCCNC(N)=N)=O)CCCCN)=O)=O)[C@H](NC1=O)CO

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