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Product Information:

AMG-510

AMG-510 is a specific covalent inhibitor of KRAS G12C with potential antineoplastic activity.

Cat. No.: EX-A3538    Purity: >99%
AMG-510
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg435In-stock
250mg600In-stock
500mg800In-stock
1g1365In-stock
5g4895In-stock
10g7832In-stock


SynonymsAMG510
Synonyms 2Sotorasib
CAS No.2296729-00-3
Purity>99%
FormulaC30H30F2N6O3
Mol Weight560.5944
Appearancesolid powder
SolubilitySoluble in DMSO, not in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Marwan Fakih, et al, Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12Cinhibitor, in advanced solid tumors. Journal of Clinical Oncology.
CoACoA of AMG-510
Smiles:O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1

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