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Product Information:

VX809

Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.

Cat. No.: EX-A178    Purity: >99% by HPLC
VX809
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g685In-stock
5g2055In-stock
10g3055In-stock


CAS No.936727-05-8
Purity>99% by HPLC
FormulaC24H18F2N2O5
Mol Weight452.4069
AppearanceSolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A, 2011, 108(46), 18843-18848.
CoACoA of VX809
Smiles:CC1=CC=C(NC(=O)C2(CC2)C2=CC=C3OC(F)(F)OC3=C2)N=C1C1=CC(=CC=C1)C(O)=O

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