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Product Information:

BGT226

BGT226 (NVP-BGT226) is a PI3K/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.

Cat. No.: EX-A3430    Purity: >98%
BGT226
For research only, Do not use for Human!

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SynonymsNVP-BGT226
CAS No.915020-55-2
Purity>98%
FormulaC28H25F3N6O2
Mol Weight534.5323
Appearancesolid powder
SolubilitySoluble in DMSO, not in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Markman B, et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors. Ann Oncol. 2012 Sep;23(9):2399-408.

[2]. Chang KY, et al. Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. Clin Cancer Res. 2011 Nov 15;17(22):7116-26.
CoACoA of BGT226
Smiles:O=C(N1C2=CC=C(N3CCNCC3)C(C(F)(F)F)=C2)N(C)C4=C1C5=CC(C6=CC=C(OC)N=C6)=CC=C5N=C4

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