Product Information:
Cat. No.: EX-A2911 | Purity: >98% |
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Synonyms | 3',3'-cGAMP |
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Synonyms 2 | c-GpAp |
CAS No. | 849214-04-6 |
Purity | >98% |
Formula | C20H24N10O13P2 |
Mol Weight | 674.4113 |
Appearance | Solid powder |
Solubility | Soluble in DMSO |
Shelf Life | >2 years if stored properly |
Storage | Powder -20℃ 2 years; In solvent -20℃ 1 month; |
Shipping | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Reference: | [1]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.
[2]. Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. [3]. Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18. [4]. Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4. |
CoA | CoA of cGAMP |
Smiles: | NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@@H]4[C@@H](COP(O)(=O)O[C@H]3[C@H]2O)O[C@H]([C@@H]4O)N2C=NC3=C2N=CN=C3N)C(=O)N1 |
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