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Product Information:

BI2536

BI 2536 is a dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-β) gene transcription.

Cat. No.: EX-A2350    Purity: >98%
BI2536
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg485In-stock
250mg685In-stock
500mg985In-stock
1g1485In-stock
5g4885In-stock
10g7850In-stock


SynonymsBI 2536
CAS No.755038-02-9
Purity>98%
FormulaC28H39N7O3
Mol Weight521.6544
AppearanceSolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Malik N, et al. Suppression of IFN β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members. Biochem J. 2015 Jun 15;468(3):363-72.

[2]. Lénárt P, et al. The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1. Curr Biol. 2007 Feb 20;17(4):304-15.

[3]. Chen L, et al. BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536. ACS Med Chem Lett. 2015 May 18;6(7):764-9.

[4]. Steegmaier M, et al. BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo. Current Biology (2007), 17(4), 316-322.

CoACoA of BI2536
Smiles:CC[C@H]1N(C2CCCC2)C2=C(C=NC(NC3=CC=C(C=C3OC)C(=O)NC3CCN(C)CC3)=N2)N(C)C1=O

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