c-di-AMP

c-di-AMP (Cyclic diadenylate) is a STING agonist as well as a bacterial second messenger. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.


Cat. No.: EX-A3317	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	890	In-stock
50mg	1650	In-stock
100mg	1650	In-stock
250mg	Get quote	In-stock
500mg	Get quote	In-stock
1g	Get quote	In-stock

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Synonyms	Cyclic diadenylate
Synonyms 2	Cyclic-di-AMP
CAS No.	54447-84-6
Purity	>98%
Formula	C20H24N10O12P2
Mol Weight	658.4119
Appearance	Solid powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8). [2]. Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519. [3]. Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31. [4]. Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824.
CoA	CoA of c-di-AMP

Smiles:	O[C@H]([C@@](OP(O)(OC[C@](O[C@@H](N1C2=NC=NC(N)=C2N=C1)[C@@H]3O)([H])[C@@]3([H])O4)=O)([H])[C@](COP4(O)=O)([H])O5)[C@@H]5N6C7=NC=NC(N)=C7N=C6


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