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Product Information:

BETA-Lapachone

Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.

Cat. No.: EX-A3011    Purity: >98%
BETA-Lapachone
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg660In-stock
1g965In-stock
2g1560In-stock
5g2985In-stock
10g5560In-stock


CAS No.4707-32-8
Purity>98%
FormulaC15H14O3
Mol Weight242.2699
AppearanceRed Solid
SolubilityDMSO : 24 mg/mL (102.28 mM; Need ultrasonic) Ethanol : 8.26 mg/mL (35.43 mM; Need ultrasonic)
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Li, C J et al. “beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin.” The Journal of biological chemistry vol. 268,30 (1993): 22463-8.

[1]. Planchon, S M et al. “Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.” Cancer research vol. 55,17 (1995): 3706-11.

[1]. Kung, Hsiu-Ni et al. “In vitro and in vivo wound healing-promoting activities of beta-lapachone.” American journal of physiology. Cell physiology vol. 295,4 (2008): C931-43.

[1]. Flick, Hollie E et al. “The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1.” International journal of tryptophan research : IJTR vol. 6 35-45. 19 Aug. 2013

CoACoA of BETA-Lapachone
Smiles:CC1(C)CCC2=C(O1)C1=C(C=CC=C1)C(=O)C2=O

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