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Product Information:

CaCCinh-A01

CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively.

Cat. No.: EX-A2900    Purity: >98%
CaCCinh-A01
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg550In-stock
250mg800In-stock
500mg1150In-stock
1g1550In-stock
1g4650In-stock
10g6550In-stock


CAS No.407587-33-1
Purity>98%
FormulaC18H21NO4S
Mol Weight347.429
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloridechannel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286(3):2365-74.

[2]. De La Fuente R, et al. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloridechannel. Mol Pharmacol. 2008 Mar;73(3):758-68.

[3]. Pin-Yi Liu, et al. TMEM16A Inhibition Preserves Blood-Brain Barrier Integrity After Ischemic Stroke.Front Cell Neurosci. 2019 Aug 6;13:360.

CoACoA of CaCCinh-A01
Smiles:CC(C)(C)C1CCC2=C(C1)SC(NC(=O)C1=CC=CO1)=C2C(O)=O

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