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Product Information:

BI-3406

BI-3406 (compound I-6) is a Son of Sevenless 1 (SOS1) inhibitor with an IC50 of 6 nM.

Cat. No.: EX-A3418    Purity: >98%
BI-3406
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg385In-stock
250mg500In-stock
500mg750In-stock
1g1150In-stock
5g3550In-stock
10g5375In-stock


SynonymsBI 3406
CAS No.2230836-55-0
Purity>98%
FormulaC23H25F3N4O3
Mol Weight462.4648
Appearancesolid powder
SolubilitySoluble in DMSO,Ethanol
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.

[2]. Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.

CoACoA of BI-3406
Smiles:CC1=NC(N[C@@H](C2=CC(C(F)(F)F)=CC(N)=C2)C)=C3C=C(O[C@@H]4COCC4)C(OC)=CC3=N1

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